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Validated Methods
Bioanalytical Laboratory Validated Bioanalytical Methods

July 2008
(*Latest methods and changes are highlighted.)

Drug
LOQ, ng/mL
Technique
Matrix
Acetaminophen
100
LC-MS
Human Plasma
Acyclovir
20
HPLC-FL
Human Plasma
Amitriptyline
1
HPLC-UV
Human Plasma
Amitriptyline
0.4
LC-MS/MS
Human Plasma
Nortriptyline
0.4
 
 
Amlodipine
0.1
LC-MS/MS
Human Plasma
Anastrozole
0.1
LC-MS/MS
Human Plasma
Atenolol
12.8
HPLC-FL
Human Whole Blood
Atomoxetine
2.001
LC-MS/MS
Human Plasma
4-Hydroxyatomoxetine
1.937
N-Desmethylatomoxetine
1.999
Atorvastatin 0.4 LC-MS/MS Human Plasma
o-hydroxyatorvastatin 0.4    
p-hydroxyatorvastatin 0.04    
Azithromycin
5
LC-MS
Human Plasma
Betamethasone
0.5
LC-MS/MS
Human Plasma
Betamethasone Acetate
0.5
   
Betamethasone Phosphate
2
   
Bromazepam
5
HPLC-UV
Human Plasma
Bumetanide
1
HPLC-FL
Human Plasma
Bupropion
1.0
LC-MS/MS
Human Plasma & Rat Plasma
Bupropion Erythroamino Alcohol
1.0
 
 
Bupropion Threoamino Alcohol
1.0
 
 
Hydroxybupropion
4.0
 
 
Buprenorphine
0.1
LC-MS/MS
Human Plasma & Dog Plasma
Norbuprenorphine
0.1
Buspirone
0.05
LC-MS/MS
Human Plasma & Mouse Plasma
1-(2-Pyrimidyl)Piperazine
0.2
   
Buspirone
0.4
LC-MS/MS
Human Plasma & Rat Plasma
1-(2-Pyrimidyl)Piperazine
1.6
   
Buspirone
0.039
LC-MS/MS
Human Plasma
1-(2-Pyrimidyl)Piperazine
0.156
   
6-Hydroxybupropion
0.625
   
Carbamazepine
50
HPLC-UV
Human Plasma
Carbamazepine-10, 11-Epoxide
10
   
Carvedilol
1
LC-MS/MS
Human Plasma
O-Desmethylcarvedilol
0.2
4'-Hydroxyphenylcarvedilol
0.2
   
5'-Hydroxyphenylcarvedilol
0.2
   
Cefaclor
200
HPLC-UV
Human Plasma
Cefixime
100
HPLC-UV
Human Plasma
Cefuroxime
200
HPLC-UV
Human Plasma
Celecoxib
20
HPLC-FL
Human Plasma
Cephalexin
200
HPLC-UV
Human Plasma
Chloropheneramine
0.1
LC-MS/MS
Human Plasma
Citalopram Chiral (R and S)
0.25
LC-MS/MS
Human Plasma
Demethylcitalopram (R and S)
0.2
 
 
Didemethylcitalopram (S)
0.2
 
 
Cilazapril
1
LC-MS/MS
Human Plasma
Cilazaprilat
0.250
   
Cilazapril
4
LC-MS/MS
Human Plasma
Cilazaprilat
1.000
   
Ciprofloxacin
24.999
HPLC-FL
Human Plasma
Ciprofloxacin
1500
LC-MS/MS
Human Urine
Desethyleneciprofloxacin
500
   
Sulfociprofloxacin
500
   
Oxociprofloxacin
500
   
Formylciprofloxacin
500
   
Cimetidine
12.5
HPLC-UV
Human Plasma
Citalopram
0.25
HPLC-FL
Human Plasma
Citalopram
0.25
LC-MS/MS
Human Plasma
Demethylcitalopram
0.05
   
Didemethylcitalopram
0.05
   
Citalopram
0.25
LC-MS/MS
Human Plasma
Demethylcitalopram
0.126
   
Didemethylcitalopram
0.025
   
Clarithromycin
20
LC-MS
Human Plasma
Clavulanic Acid
100
LC-MS/MS
Human Plasma
Clonazepam
0.1
LC-MS/MS
Human Plasma
Cloxacillin
100
HPLC-UV
Human Plasma
Clozapine
0.1
LC-MS/MS
Human Plasma
Cyproterone Acetate
0.3
LC-MS/MS
Human Plasma
Ethinyl Estradiol
0.015
   
Dextromethorphan/
0.1
LC-MS/MS
Human Plasma
Dextrorphan/
1
   
Pseudoephedrine
1
   
Didanosine
10
LC-MS/MS
Human Plasma
Diflunisal
500
HPLC-UV
Human Plasma
Diltiazem
3
HPLC-UV
Human Plasma
Desacetyldiltiazem
1
   
N-Desmethyldiltiazem
3
   
Diltiazem
0.781
LC-MS/MS
Human Plasma
Desacetyldiltiazem
0.195
   
N-Desmethyldiltiazem
0.391
   
Doxazosin (achiral)
0.5
HPLC-FL
Human Plasma
Doxepin
2
HPLC-UV
Human Plasma
Nordoxepin
1
   
Doxycycline
80
HPLC-UV
Human Plasma
Efavirenz 0.02
LC-MS
Human Plasma
Enalapril
0.25
LC-MS/MS
Human Plasma
Enalaprilat
0.25
   
Eprosartan
5
LC-MS/MS
Human Plasma
Etodolac
250
HPLC-UV
Human Plasma
Exemestane
0.2
LC-MS/MS
Human Plasma
Famotidine
5
HPLC-UV
Human Plasma
Felodipine
0.05
LC-MS/MS
Human Plasma
Fenofibric acid
10
HPLC-UV
Human Plasma
Fenofibric acid
49.996
HPLC-UV
Human Plasma
Fentanyl
0.02
LC-MS/MS
Human Plasma
Fexofenadine
5
HPLC-FL
Human Plasma
Fluconazole
100
HPLC-UV
Human Plasma
Fluoxetine
0.5
LC-MS
Human Plasma
Norfluoxetine
0.5
   
Flupenthixol
0.1
LC-MS/MS
Human Plasma
Fluticasone Propionate
0.001
LC-MS/MS
Human Plasma
Fluticasone Propionate
0.005
LC-MS/MS
Human Plasma
Fluvastatin
1.999
LC-MS/MS
Human Plasma
Fluvoxamine
0.5
LC-MS/MS
Human Plasma
Gabapentin
74.998
LC-MS/MS
Human Plasma
Ganciclovir
30
HPLC-FL
Human Plasma
Gatifloxacin
25
HPLC-FL
Human Plasma
Glimepiride
2
LC-MS/MS
Human Plasma
Glipizide 2.5 LC-MS/MS Human Plasma
Glyburide
2
LC-MS
Human Plasma
Griseofulvin
15
LC-MS/MS
Human Plasma
Granisetron
0.02
LC-MS/MS
Human Plasma
Guaifenesin
10
LC-MS
Human Plasma
Hydrochlorothiazide 5 LC-MS Human Plasma
Hydrocodone
0.4
LC-MS/MS
Human Plasma
Hydrocodone+Ibuprofen
1.0/100
LC-MS/MS
Human Plasma
Hydromorphone
1
   
Hydromorphone
0.05
LC-MS/MS
Human Plasma
Ibuprofen
400
HPLC-UV
Human Plasma
Indapamide
12.6
HPLC-UV
Human Plasma
Indapamide
10
HPLC-UV
Human Whole Blood
Indomethacin
10
HPLC-UV
Human Plasma
Itraconazole
1.0
LC-MS/MS
Human Plasma
Hydroxy Itraconazole
1.0
   
Ketoprofen
300
HPLC-UV
Human Plasma
Lamotrigine
20
HPLC-UV
Human Plasma
Lansoprazole
LC-MS/MS
Human Plasma
Leuprolide
0.025
LC-MS/MS
Human Plasma
Letrozole
0.5
LC-MS/MS
Human Plasma
Levetiracetam
0.5
LC-MS/MS
Human Plasma
Lisinopril
0.25
LC-MS/MS
Human Plasma
Lisinopril
1
LC-MS/MS
Human Plasma
Loratadine
0.1
LC-MS/MS
Human Plasma
Descarboethoxyloratadine
0.1
   
Loratadine/Pseudoephedrine
0.1/2.5
LC-MS/MS
Human Plasma
Descarboethoxyloratadine
0.1
   
Losartan
4.010
LC-MS/MS
Human Plasma
Losartan Hydroxy Acid
3.998
   
Lovastatin
0.1
LC-MS/MS
Human Plasma
Lovastatin Hydroxy Acid
0.1
   
Medroxyprogesterone Acetate
0.02
LC-MS/MS
Human Plasma
Mefenamic acid
50
HPLC-UV
Human Plasma
Megestrol Acetate
1
LC-MS/MS
Human Plasma & Dog Plasma
Meloxicam
30.0
HPLC-UV
Human Plasma & Dog Plasma
Meloxicam
1
LC-MS/MS
Human Urine
Metaxalone
5
LC-MS
Human Plasma
Metoprolol
1
LC-MS/MS
Human Plasma
Metformin
10
LC-MS/MS
Human Plasma
Metformin
2
LC-MS
Human Urine
Methylprednisolone
0.4
LC-MS/MS
Human Plasma
Metoprolol
2.5
HPLC-UV
Human Plasma
Mirtazapine
0.5
LC-MS/MS
Human Plasma
Misoprostol Acid/Diclofenac
0.01/19.997
LC-MS/MS
Human Plasma
Mycophenolate Mofetil
LC-MS/MS
Human Plasma
Mycophenolic Acid?
Nabumetone metabolite (6-MNA)
500
HPLC-FL
Human Plasma
Nadolol
0.5
HPLC-FL
Human Plasma
Nadolol/Bendroflumethiazide 2.000/1.000 LC-MS/MS Human Plasma
Naltrexone
0.1
LC-MS/MS
Human & Dog Plasma
6-ß-Naltrexol
0.1
   
Naltrexone
1.0
LC-MS/MS
Human Urine
6-ß-Naltrexol
10.0
   
Naproxen
500
HPLC-FL
Human Plasma
Nefazodone
6.25
LC-MS
Human Plasma
2-Hydroxynefazodone
1.88
   
m-Chlorophenylpiperazine
1.25
   
Nifedipine
0.5
LC-MS/MS
Human Plasma
Nifedipine
0.5
LC-MS or
LC-MS/MS
Human Plasma
Nitrofurantoin
20
HPLC-UV
Human Plasma
Nizatidine
10
HPLC-UV
Human Plasma
N-Desmethylnizatidine
5
   
Nortriptyline
1
HPLC-UV
Human Plasma
Norfloxacin
20
HPLC-FL
Human Plasma
Omeprazole
1
LC-MS/MS
Human Plasma
Ondansetron
0.5
LC-MS/MS
Human Plasma
Oxaprozin
1000
HPLC-UV
Human Plasma
Oxcarbazepine
10
LC-MS/MS
Human Plasma
10,11-dihydro-10-Hydroxycarbamazepine
50
   
Oxycodone
0.5
LC-MS/MS
Human Plasma
Noroxycodone
0.5
   
Oxymorphone
0.1
   
Oxybutynin
0.16
LC-MS/MS
Human Plasma
Desethyloxybutynin
1.56
   
Pantoprazole
20.001
LC-MS
Human Plasma
Paroxetine
0.2
HPLC-FL
Human Plasma
Paroxetine
1.563
HPLC-FL
Human Plasma
Pentoxifylline
1.3
LC-MS/MS
Human Plasma
Hydroxy Pentoxifylline
4.3
   
and CPDX
4.3
   
Phenylephrine (Total)
4
LC-MS/MS
Human Plasma
Phenytoin
40
HPLC-UV
Human Plasma
Pindolol
2
HPLC-FL
Human Plasma
Pramipexole
0.04998
LC-MS/MS
Human Plasma
Pravastatin
0.25
LC-MS/MS
Human Plasma
3-a-Hydroxy Pravastatin
0.25
   
Pravastatin
1
LC-MS/MS
Human Plasma
3-a-Hydroxy Pravastatin
1
   
Prazosin
0.1
HPLC-FL
Human Plasma
Primidone
200
LC-MS/MS
Human Plasma
Phenobartital
200
   
Phenylethylmalonamide
200
   
Propranolol
0.4
HPLC-FL
Human Plasma
4 -Hydroxypropranolol
0.8
   
Ramipril
0.05
LC-MS/MS
Human Plasma
Ramiprilat
0.05
   
Ranitidine
25
HPLC-UV
Human Plasma
Rosiglitazone
1.996
LC-MS/MS
Human Plasma
Sertraline
0.25
LC-MS/MS
Human Plasma
N-Desmethylsertraline
0.25
   
Simvastatin
0.1
LC-MS/MS